UNANESTHKTIZKD POIKILOTHERMIC DOG— KELLER 



7Z 



PRE-OPERATIVE 38 36 34 32 30 28 



DEEP COLONIC TEMPERATURE 'C 



Fig. 10. — Relationship of glomerular filtration rate to deep colonic temperature in Dog 504. 

 Figures in parentheses indicate number of times clearances were done at that particular core 

 temperature. 



body core temperatures, but in contrast to glomerular filtration rate and renal 

 plasma flow in most instances, the greatest reduction occurred characteristically at 

 mild degrees of hypothermia. The data on 4 dogs are charted in figure 11. Here again 

 the decrease in tubular maxima in the dog, which approximated a straight-line fall, 

 was in a preparation which approximated the completely poikilothermic status. Per- 

 haps, therefore, the precipitous fall during early hypothermia can be correlated with 

 the retention of remnantal heat regulatory ability. 



The ability of the kidney to concentrate, as measured by osmotic flow-load 

 curves, was not noticeably afi^ected by core temperatures of 28° C. 



Cardiovascular.^ Observations were made before and during the induction of 

 hypothermia and during rewarming in several unanesthetized poikilothermic dogs 



t The author is indebted to Lt. Frederick R. Mugler, Jr. for cardiovascular observations. 



