RENAL FUNCTION— MOVER, MORRIS and DE BAKEY 213 



TABLE III 



Renal Glomerular 

 Blood blood filtration Urine 



pressure flow rate volume 



(mm. Hg) (ml/min.) (ml/min.) (ml/min.) 



Control observations (98° F.) 130/80 1253 90 .9 



Hypothermia (91° F.) 100/80 782 72 .8 



Aortic occlusion (91° F.) 130/80 



After occlusion (91° F.) 124/80 447 Z1 1.4 



Rcwarmed (100° F.) 128/80 920 104 .8 



was seen with hypothermia. The urine volume, however, was not significantly re- 

 duced and was increased after occlusion while still hypothermic. Again, return in 

 function was incomplete immediately after release of the clamps compared to pre- 

 occlusion hypothermic values. However, after rewarming, renal function approx- 

 imated the control observations. 



SUMMARY 



It was found that the renal functional response of these four patients to hypo- 

 thermia was similar to that of the dog. Glomerular filtration and renal blood flow 

 were moderately depressed. These returned to or towards control levels with 

 normothermia. Hypothermia did not prevent renal damage due to ischemia if the 

 period of renal artery and aortic occlusion was prolonged. In the one case of 

 combined aortic and renal artery occlusion for an extended period of time, severe 

 irreversible renal damage occurred in spite of hypothermia. 



REFERENCES 



1. Moyer, J. H., and Handley, C. A. : Renal and cardiovascular response to ganglionic blockade 



with pendiomide and a comparison with hexamethonium and arfonad, J. Pharma. & Exp. 

 Therapy 113: 383-392, 1955. 



2. Mills, L. C, and Moyer, J. H. : The acute effects of hexamethonium on renal hemodynamics 



in normntcnsive and hypertensive human subjects, Am. J. Med. Sci. 226: 1-15, 1953. 



