METABOLISM AND DETOXIFICATION-GRAY. RUECKERT and RINK 231 



HEAT 

 < 24**c > ON < ZT'^c > 



LU 

 Q. 



300- 

 200- 



100- 

 50- 



M.S.50mgm 



CONJ. 



FREE 



1 r 



I 



I r 



5 6 



12 3 4 



HOURS 



Fig. 3. — EiYect of tciniieratiirc on morpliint- iiK-taljolism by perfused live 



100 



^ 



.24t., 



,M.S.,50mg. 



60 70 80 90 100 NO 120 130 

 MINUTES 



Fig. 4. — Morphine metabolism by perfused liver at 24° C. 



