BRAIN COOLING— JENSKN, PARKINS and VARS 273 



TABLE II 

 Vkna Cavai. Occlusion in DikI'KRentially Cooled Docs: Cardiac Deaths 



Lowest brain temperature 



, ^ ^ Lowest 



Dog Perfused Uiiperfused rectal Time 



no. side side temp. occluded Result 



12 15° C. 18° C. 30° C. 15 mill. Died. Fibrillation 



21 18° C. — 29° C. 20 min. Died. Fibrillation 



2>2 20° C. 20° C. 31° C. 25 min. Died. Asystole 



TABLE III 



Differential Cooling in Dogs (No Occlusion) 



(Brain temperatures reduced to 12°-18° C. No neurological damage.) 



Lowest brain temperature 



I '^ ^ Lowest Result 



Dog Perfused L'nperfused rectal , '^ , 



no. side side temp. Alive Defect 



20 13° C. 14° C. 25° C. Yes No 



22 12° C. 12° C. 27° C. Yes No 



24 18° C. 19° C. 30° C. Yes No 



25 15° C. 20° C. 30° C. Yes No 



26 18° C. 18° C. 29° C. Yes No 



^i 14° C. 17° C. 24° C. Yes No 



il 16° C. 21° C. 27° C. Yes No 



39 18° C. 24° C. 26° C. No Arrest 



TABLE IV 



Differential Cooling in Dogs (No Occlusion) 



(Brain temperatures reduced to 8°-12° C. Neurological damage.) 



Lowest brain temperature 



I '^ ^ Lowest 



Dog Perfused Unperfused rectal 



no. side side temp. Result 



16 10° C. 12° C. 27° C. Disoriented 



17 9°C. — 26° C. Motor ataxia 



18 9°C. — 26° C. Motor ataxia 



23 12° C. 13° C. 25° C. Motor ataxia 



30 8°C. 10° C. 26° C. Motor ataxia 



16 10° C. 12° C. 27° C. Disoriented 



14 9°C. 10° C. 28° C. Comatose. Died 



15 8°C. 10° C. 24° C. Comatose. Died 



diately while one developed an asystole which reverted to fibrillation. Cardiac 

 massage, electrical defibrillation, and appropriate drugs were tried but in these 

 animals a normal, efl:ective rhythm was not re-established. In addition two animals 

 not shown recovered initially but died during the post-operative period of unde- 

 termined causes. 



In 16 animals the circulation was not occluded. Eight of these, shown in table III, 

 were subjected to brain temperatures of from 12° to 18° C. One animal died during 

 the cooling period but the remaining seven recovered completely. Eight dogs, shown 

 in table IV, were cooled dififerentially for long periods of time and to brain tempera- 

 tures ranging from 8° to 12° C. There was evidence of gross sensory and motor 

 disturbances in all of these. Two animals remained comatose and died after several 

 days. In each case, gross examination of the brain was unrewarding. Four dogs 



