PLATELETS— VILLALOBOS, ADELSON and RILEY 



193 



WBC 



100 



90 



80 



70 



DROP ^° 



in % f 



original 



level 



50 



40 



30 



20 



10 



RESPONSE OF WBC 

 TO HYPOTHERMIA 



Control 

 Dogs 



Splenectomized 

 Dogs 



Fig. 3. 



Hepatectomized 

 Dogs 



Hepatectomized- 



Splenectomized 



Dogs 



and the two procedures together reduced the lowering of platelets considerably. 

 Similar results, although not quite as clear-cut, were obtained wath white cell counts. 

 Summary. The decrease in platelet count and probably white cell count in hypo- 

 thermic dogs is due to the sequestration of platelets and white cells, and not to their 

 destruction. Catheterization studies indicate that some of the secjuestration occurs 

 in the liver and probably also in the spleen. However, since hepatectomy and 

 splenectomy did not completely abolish the platelet and white cell drops, we feel 

 that other sinusoidal organs such as the bone marrow may also play a role in the 

 sequestration of platelets and white cells. 



