HEMORRHAGIC SHOCK— FRIEDMAN, DAVIDOFF and FINE 3/3 



TABLE II 



Effect of Hypothermia in Severe and Prolonged Hemorrhagic Shock on Tolerance to 

 Hypotension and on Survival Rate 



T3^ S u 



^ 





^ c t; o . 



1 ype 01 3M-I n^« rt— ortj^owra 



•r: ^ 3 v.- " 3 o 

 expei-iment 'Z ° C"^^ S-°^~^ P^ 



Control — Shock without hypothermia or 

 antibiotic 200+ 5 53 40 6 <20 



Group I — Hypothermia prior to shock, 

 no antibiotic 14 7 44 17 30 



Group II — Hypothermia prior to shock, anti- 

 biotic* with transfusion and for 3 days 

 thereafter 9 7.3 46 12 — 100 



Group HI — Hypothermia after induction of 

 shock, antibiotic witli transfusion and for 

 3 days thereafter 10 7.0 60 26 31 30 



" Penicillin and streptomycin. 



tions is so much less than in uncooled dogs that transfusion in most cases is not 

 required to support the circulation for at least eight hours. The protection afforded 

 the circulation is also reflected in (a), the excellent and sustained pressor response 

 to transfusion given at this time; (b), the subsequent restoration of a normal 

 cardiac output as the body temperature rises to normal; (c), the return to near 

 normal of the arterio-venous oxygen difference (table III). 



Usually such a response is prognostic of recovery. But the survival time in the 

 dogs of Group I (no antibiotic) average 30 hours, and permanent recovery did not 

 occur in a single instance. Because death occurred after such a relatively long inter- 

 val as compared to that for uncooled dogs, we suspected that some supervening 



TABLE III 



Cardiovascular and Respiratory Dynamics in Dogs Pre-cooled Under Ether and 

 Subsequently Subjected to Hemorrhagic Shock 



d £- 



.2 o'« 



„if « *^^ '-S^ u.Z-: §.S g-'^S .2.S 



2|u SXj| Sii-S tS-^- fc-p ^i, B^< 8^ -^-j,, -as 

 ^S- <^^ i--- cj°" <^ <~^ 'X."^ C^ >^^ c:" 

 No hypothermia or shock 38 124 114 3592 22.9 3.7 18.3 97.4 18.7 30 

 Hypothermia 



(under ether) 28 104 109 1909 23.8 3.4 11.3 50.6 23.0 27 



Hypothermia and shock 



(no ether) 22 30 70 181 22.9 12.6 4.9 20.5 24.2 16 



After transfusion and rise 



in body temperature... 33.5 112 95 3355 22.7 5.5 14.8 123.0 13.0 18 

 Number of experiments 



represented in each 



value listed (23) {23) (23) (4) (4) (4) (4) (4) (4) {23} 



