HEMOKKMAGIC SI lOCK— FR[f':DMAN, DAVIDOFF and FIXF 



379 



TABLE 1 



Ei'i'KCT OF 1 Ivi'<iriii:i<MiA UPON Rksistance to Bacteria Givkn ouking ok Aktkr Shock 



OF Two Hours' Duration " 



No. Survivors 



of , '- 



Group Kxijcriincut doKs Number 



I E. coli intravenously in normal dogs 10 10 



II 2-liour shock in norniothermic dogs 10 — 



III 2-hour shock in norniothermic dogs, E. coli intra- 

 venously during shock or at any time up to 



24 hours after transfusion ,iO 



I\' Hypothermia (28° C.) induced prior to 2-hour 



shock, E. coli intravenously during hypotensive 

 period — warmed to normal temperature after 



transfusion 8 6 



V Same as Group I\' excei)t E. coli given after body 



temperature was back to normal'' 14 11 



% 



100 



90 







75 



79 



» Hemorrhagic shock — bleeding to blood pressure 30 mm. Hg for 2 hours followed by transfusion of all shed 

 blood. 



'' The results for E. coli — four of these experiments were done with a coagulase-positive hemolytic staphylo- 

 coccus aureus, to which normal and 2-hour shock dogs respond as they do to E. coli. 



the two-hour shock period, with intravenous bacteria given either during hypo- 

 thermia and hypotension (Group IV) or after rewarming (Croup V), the result 

 is that about three-quarters of the animals survive. 



The nature of this protection we cannot begin to state, although we may ha^■e 

 some inkling of a possible mechanism as a result of our recent cooperation with 

 Dr. Pillemer of Western Reserve. Dr. Pillemer has recently described a substance 

 in serum which he called properdin and which he believes, and we believe with him, 

 may play an important part in natural resistance to bacteria. 



Figure 1 shows a characteristic response of properdin titer in a dog subjected to 



under 3 units 



8 10 12 

 TIME(DAYS) 



Fig. 1. — Response of properdin titre in dog subjected to heinorrhagic hypotension. 



