384 



90 



80 - 



70- 



60 



PHYSIOLOGY OF INDUCED HYPOTHERMIA 



89% 



^ 50 



Oh 



40 



30 



20 



2^ 



26 



4 

 20 



16 



■ No survivors 

 No. cnimols 



Cooling CniorpromozineChlorpromoiineChlorpromozine Ctilorpromoiine 

 5mg. 5mg. 100 mg. lOOmg 



+ Cooling +Cooling 



Fig. 2. — Ultimate survival in experimental hemorrhagic shock. 



average period of hypotension for the control dogs was 3 hours, 54 minutes, for 

 the hypothermic animals 5 hours; for the 5 mg. chlorpromazine-treated 6 hours, 

 6 minutes; for the 50 mg. chlorpromazine-treated 6 hours, 54 minutes; for the 

 5 mg. chlorpromazine and hypothermia group 6 hours, 26 minutes; and for the 

 50 mg. chlorpromazine and cooled group 7 hours, 36 minutes (fig. 4). 



These results are affected by an uncontrollable variable in the experiment that 

 two of the five forms of therapy produced. The amount of blood lost was essentially 

 the same for the hypothermic, 5 mg. chlorpromazine-treated and control dogs, but 

 it was greatly reduced in those receiving the autonomic blocking agent in large 

 doses, either alone or when combined with surface cooling (table I). Also notable 



TABLE I 

 Experimental Hemorrhagic Shock 



Initial 



blood 



pressure 



(mm. Hg) 



Control ">^ 



Hypothermia "^ 



Chlorpromazine 50 mg 80 



Chlorpromazine 5 mg 84 



Hypothermia -f- Chlorpromazine 50 mg 73 



Hypothermia + Chlorpromazine 5 mg 90 



Time 



to reach 



maximum 



bleeding 



volume 



Ihr. 



1 hr. 18 min. 

 3 hr. 24 min. 



2 hr. 24 min. 



3 hr. 51 min. 

 2 hr. 32 min. 



Maxinumi 



bleeding 



volume 



(cc./Kg.) 



51.8 



51.4 

 41.1 

 52.1 

 42.4 

 53.5 



