RENAL FUNCTION— MOVER, MORRIS and DE BAKEY 



205 







Mean Blood Pressure 

 mm Hg 



Glomerular 

 Filtration Rate 

 cc/min. 



Renal Blood Flow 



cc./mln. 



Fig. 6. — The effect of increasing the blood pressure to normotensive levels with norepineph- 

 rine during hypothermia. This did not improve glomerular filtration rate nor did it increase 

 renal blood flow. 



The important effects of ischemia on renal hemodynamics produced Ijv renal 

 artery occlusion (subgroups 2B and 2C) are summarized in figures 7 A and 7B. 

 When only the renal artery was occluded and the aorta was left intact (group 2B), 

 observations three days later indicated that glomerular filtration rate and renal 

 blood flow were reduced to about | of the control values (68 and 60 per cent 

 respectively). There was no effect on plasma-scdiimi and potassium. The unoc- 

 cluded kidney (control kidney) showed no alterations in renal function for the 

 group. 



When both the aorta and renal artery were occluded (group 2C), the left kidney 

 (occluded kidney) was damaged severely but the right kidney (unoccluded kidney) 

 was not damaged. Three days after the occlusion, the glomerular filtration rate in 

 the left kidney (occluded) was reduced to 8 per cent of the control levels and 

 renal blood flow to 7 per cent. At the same time, glomerular filtration rate in the 

 right kidney was 100 per cent of the control and the renal blood flow was 99 per 

 cent of the control value. Under these circumstances the right kidney served as a 

 control. A combination of renal artery occlusion and occlusion of the aorta pro- 

 duced the greatest renal damage in the occluded kidney (left) of any of the 

 methods employed. This is probably due to a reduction in blood flow to the kidney 

 through the renal artery as well as collateral flow through the renal cortex via the 

 lumbar vessels and perhaps through the adrenal gland. These observations also indi- 

 cate that very low pressures (below 32 mm. Hg) have a protective effect on the 

 kidney since the right kidney was not damaged as a result of the occlusion of 

 the aorta. 



