II Reversible Reactions with Oxygen and Carbon 

 Monoxide — con tinued 



PAGE 



5 The Intermediate Compound Hypothesis in relation to the 

 Equilibria and Kinetics of the Reactions of Haemoglobin 

 with Oxygen and Carbon Monoxide 83 



Professor F. J. W. Roughton, F.R.S., Department of Colloid 

 Science, Cambridge University 



6 Some Physico-Chemical Evidence regarding the Structure 



of Haemoglobin 95 



Professor Jeffries Wyman, Jr., Biological Laboratories, 

 Harvard University 



III Analysis and Amino Acid Composition 



1 The Amino Acid Composition of the Blood and Muscle of 



the Horse 109 



G. R. Tristram, Ph.D., Department of Biochemistry, 

 Cambridge University 



2 The Chemical Composition of Human Myoglobin 1 1 5 



Professor A. Rossi-Fanelli, Institute of Biological 

 Chemistry, University ofPavia 



3 The Free Amino Groups of Various Haemoglobins 1 2 1 



R. R. Porter, Ph.D., and F. Sanger, Ph.D., Department 

 of Biochemistry, Cambridge University 



4 The Simultaneous Spectrophotometric Determination of 

 Haemoglobin and Myoglobin in Extracts of Human 

 Muscle 1 25 



Christian de Duve, M.D., Lic.Sc, Biochemical Institution 

 of the Medical Nobel Institute, Stockholm 



IV X-Ray Crystallography 



1 An X-Ray Investigation of Haemoglobin and Haemocyanin 



in Aqueous Solution 131 



D. G. Dervichian, Dr. es Sc, G. Fournet, and A. Guinier, 

 Institut Pasteur and Conservatoire National des Arts, et 

 Metiers, Paris 



2 Recent Developments in the X-Ray Study of Haemoglobin 135 



M. F. Perutz, Ph.D., Cavendish Laboratory and Molteno 

 Institute, Cambridge University 



