h. m. jope and j. r. p. o'brien 



of Pathology, Radcliffe Infirmary, Oxford and Dr. R. Barer, Department 

 of Human Anatomy, Oxford, for other photographs. This research was 

 supported by a grant to one of us (H.M.J.) from the Medical Research 

 Council. 



Received September 1948 



REFERENCES 



1 Hunefeld, F. L. Die Chemismus in der thierischen Organisation, Leipzig, 



(1840) 160 



2 Funke, O. Atlas of physiological chemistry, supplement to Lehmann's physio- 



logical chemistry, (London, 1852) Plate X, Figs 1 and 6 



3 Reichert, E. T. and Brown, A. P. The Crystallography of the Hemoglobins, 



Carnegie Institute of Washington, Pub. No. 116 (1909) 317 



4 Amantea, G. Ber. ges. Physiol. 23 (1924) 167 



5 Perrier, C. and Janelli, P. Arch. Fisiol. 29(1931)289 



6 Haurowitz, F. Hoppe-Seyl. Z. 232 (1935) 125 



7 Green, A. A., Cohn, E. J. and Blanchard, M. J. biol. Chem. 109 (1935) 631 



8 Cannan, R. K. and Redish, J., in Mudd, S. and Thalhimer, W. Blood sub- 



stitutes and blood transfusion Springfield and Baltimore (1942) 147 



9 Drabkin, D. L. Amer. J. med. Sci. 209 (1945) 268 



10 — /. biol. Chem. 164 (1946) 703 



11 Perutz, M. F. Nature, Lond. 160 (1947) 786 



12 Pauling, L. and Coryell, C. D. Proc. nat. Acad. Sci., Wash. 22 (1936) 210 



13 Coryell, C. D., Stitt, F. and Pauling, L. /. Amer. chem. Soc. 59 (1937) 633 



14 Hoch, H. Unpublished work (1948) 



15 Andersch, M. A., Wilson, D. A. and Menten, M. L. /. biol. Chem. 153 



(1944) 301 



16 Jope, E. M. This volume, p. 216 



17 Porter, R. R. and Sanger, F. Bio-chem. J. 42 (1948) 287 



18 Haurowitz, F. Hoppe-Seyl. Z. 186 (1930) 14; 



19 Darrow, R. R., Nowakovsky, S. and Austin, M. H. Arch. Path. Lab. Med. 

 30 (1940) 873 



20 McCarthy, E. F. and Popjak, G. Nature, Lond. 159 (1947) 198 



21 Gutfreund, H. Personal communication (1948) 



22 Roche, J., Derrien, Y. and Moutte, M. C.R. Soc. Biol., Paris 135 (1941) 1235 



23 Morris, C. J. O. R. Unpublished work (1946) 

 21 Cecil, R. Unpublished work (1947) 



25 Hartley, G. S. Quart. Rev. chem. Soc. 2 (1948) 160 



26 Green, A. A. /. Amer. chem. Soc. 55 (1933) 2335 



27 — J. biol. Chem. 93(1931)495 



* 8 Boyes-Watson, J., Davidson, E. and Perutz, M. F. Proc. roy. Soc, A. 191 

 (1947) 83 



278 



