CONTENTS 



PAGE 



Foreword .......... v 



Preface .......... vii 



Part I 

 REVIEW OF THE LITERATURE 



HAPTER 



I. The Discovery of the Mast Cells ..... 3 

 II. The Mast Cell in Evolution 5 



Invertebrates; Vertebrates, including Man. 



III. The Blood Mast Cell, Basophil or Mast Leucocyte . 17 



Tissue Mast Cells in Bone Marrow. 



IV. Mast Cells in Pathological Conditions . . . .21 



Chronic Inflammation and Tumours. 



V. The Mast Cell and Heparin 28 



Part II 

 EXPERIMENTAL 

 VI. Introduction ......... 33 



The Mast Cell and Carcinogenesis; The Problem of the Shocked Dog. 



VII. Detailed distribution of Mast Cells in Cattle and in the Rat 39 



Relationship of Mast Cells to Serous Membranes and Blood Vessels. 



VIII. The Effects of Histamine-Liberators on the Mast Cells of 



the Rat ......... 59 



IX. Histamine in Tissue Mast Cells: Normal Tissues . . 71 



X. Histamine and Heparin in Tissue Mast Cells: Pathological 



Conditions ......... 77 



XI. The Effects of a Specific Histamine-Liberator, Compound 



48/80, on the Mast Cells of the Rat .... 93 



XII. The Effects of the same Histamine-Liberator on two dif- 

 ferent Species, Mouse and Rat . . . . .109 



ix 



