COMPOUND 48/80 ON RAT 



It is as yet too soon to judge the merit of this new approach to the problem 

 of the release of histamine from mast cells by the chemical histamine-liberators; 

 its value is rather that it opens up the way to fresh experimentation. As 

 mentioned earlier, it is certainly not necessary that either degranulation or 

 disruption occur for histamine to escape from the mast cell. The chemical 

 liberators are associated with pathological events. 



Important as the mast cell may be in accounting for the bulk of tissue 

 histamine, it is desirable that we should next enquire whether there might not 

 exist binding sites for histamine other than mast cells and whether such binding 

 sites also release their histamine in response to the 'histamine-liberators'. 



131 



