PREVITE AND BERRY 



19. Schneider, H. A. 1949. Nutrition of the host and natural re- 



sistance to infection. IV. The capability of the double strain 

 inoculation test to reveal geneticallydetermined differenced in 

 natural resistance to infection. J, Exp. Med. 89: 529-539. 



20. Schneider, H, A., and N. Zinder. 1956. V. An improved assay 



employing genetic markers in the double strain inoculation 

 test. J. Exp. Med. 103: 207-224. 



21. Schonbaum, E. 1960. Adrenocortical function in rats exposed to 



low environmental temperatures. Federation Proc. 19: 85-88. 



22. Selye, H. 1955. Stress and disease. Geriatrics 10: 253-261, 



23. White, C, 1952. The use of ranks in a test for significance for 



comparing two treatments. Biometrics 8: 33-41. 



DISCUSSION 



BLAIR: I was particularly interested in the development of 

 the hypothermia of the Serratia endotoxin, I wonder if here a- 

 gain we aren't faced with the problem of the species differences 

 in experimental work of this nature. Maxwell, several years ago, 

 using dogs — I am sorry, you used Serratia endotoxin also — 

 uniformly obtained hyperpyrexia, and his animals died in the 

 classic picture of septic shock with a high fever. 



PREVITE: In response to that, I would say that mice seem 

 to be peculiar animals in that respect. Although I don't pro- 

 fess to have tremendous knowledge concerning the effects of 

 endotoxin, from what I have read, it seems as if the mouse is 

 one of the few animals that responds to this poison with a lowered 

 body temperature. Most animals, including man and rabbits, 

 respond with hyperthermia. These divergent responses again 

 point out significant species differences. 



234 



