SPECIFIC AND NONSPECIFIC RESISTANCE 



Temperature 



Treatment 



Mortality ratios at lu days 



21® C 



Normal 

 Immunized 

 Zymosan 

 Endotoxin 



0/20 

 0/20 

 0/20 

 3/20 



2«> C 

 (Unacclima- 

 tized) 



Normal 

 Immunized 

 Zymosan 

 Endotoxin 

 Cold Control 



15/20 

 0/20 

 8/20 



20/20 

 0/20 



2° C Normal 

 (Acclimatized) 



Immunized 



Zymosan 



Endotoxin 



Cold Control 



1/20 

 0/20 

 U/20 

 7/20 

 0/20 



Table XVII. Coxsackie B-I infection mortality in adult mice. Challenge = 10 x 10^ 

 PFU intraperitoneally. 



procedures protected the animals under these conditions. With the 

 doses and routes of administration employed in this experiment, zy- 

 mosan and endotoxindid not enhance host resistance to viral disease. 



Although most deaths of animals in the preliminary experiment 

 occurred between 4 and 7 days post- challenge and probably the re- 

 sults of the first definitive experiments were valid at 7 days, further 

 investigation was required in order to see if acclimatization was 

 beneficial to the challenged animals. Therefore, a repeat experiment 

 of the same design was completed, but larger groups of mice were 

 employed. The animals kept at 2° C were supplied with adequate 

 amounts of food and water to rule out nutritional factors that might 



185 



