MIYA, MARCUS AND PHELPS 



Temperature 



Treatment 



Hortality ratios at 7 days 



210 C 



Normal 

 Immunized 

 Zymosan 

 Endotoxin 



0/10 

 0/10 

 0/10 

 1/9 



2° C 

 (Unacclima- 

 tized) 



Normal 

 Immunized 

 Zjrmosan 

 Endotoxin 

 Cold Control 



7/10 

 0/10 

 3/10 



e/8 



0/10 



2° C 

 (Acclimatized) 



Normal 

 Immunized 

 Zymosan 

 Endotoxin 

 Cold Control 



0/10 

 0/10 

 2/10 

 3/10 

 0/10 



Table XVI. Effect of specific and nonspecific immunization on resistance of adult 

 mice challenged with Type B-1 Coxsackie virus intraperitoneally. Challenge = 10 x 

 104 PFU. 



summarized in Table XVI. The mortality ratios were taken only for 

 7 days post- challenge because the mice were inadvertently not fed 

 one weekend, and most of the animals in the cold died, presumably 

 from starvation. However, it is of interest to briefly analyze the re- 

 sults obtained. It is seen that the virus only caused one death in 39 

 mice kept at 21" C. This death occurred in the animals receiving 

 endotoxin. It is also seen that unacclimatized mice did not fare as 

 well as acclimatized mice and, in general, exposure to 2° C de- 

 creased the host's ability to withstand Coxsackie virus challenge. Of 

 special interest is the indication that acclimatized mice seemed to 

 withstand the Type B-1 Coxsackie virus challenge that was detri- 

 mental to unacclimatized mice, although specific immunization 



184 



