SPECIFIC AND NONSPECIFIC RESISTANCE 



Number of 



Organisms 



Ambient Temperatures 



21© Q 2* C 20 C 



(grouped) (grouped) (single) 



immu- immu- immu- 



noznnal nized normal nized normal nized 



LDjQ and 20 x 10^ 

 95% (2.0 x 10^ 



Confidence to 

 Limits 200 x 10^) 



50 X 10^ 100 X 25 X 10^ 16 

 106 



(11 X 10^ (25 

 10 

 to 



I 



to 



10*> 

 (5.5 X (3.2 X 

 106 10^ 

 to to 



225 X 10^) UOO X 112 X 

 106) 10^) 



80 X 



106) 



Agglutinin 



titer 



1:32 



1:16 



1:16 



Table V. Effect of chronic cold stress (2° C) on mortality of mice challenged with 

 Staphylococcus aureus , strain Fritchie. Animals maintained for 21 days, immunized 

 and challenged at noted temperatures. *7 day mortality (dead/total), 



experiments, acclimatized and immunized mice, singly-caged 

 or in groups, did no better on challenge with S. aureus than 

 controls. 



Low Ambient Temperatures and Specific and Nonspecific Resistance 



Effect of acute exposure foUowir^ one LD cq challenge dose. 

 The animals in this experiment were maintained at 2P C during 

 the time of specific immunization or treatment with zymosan 

 or endotoxin. Following challenge with viable organisms, some 

 of the animals were immediately transferred to 2° C; others 

 were kept at 21° C as controls. The mice that were transferred 

 to . the cold room were either kept in groups of 10 or caged indi- 



173 



