SPECIFIC AND NONSPECIFIC RESISTANCE 



PREVITE: Halberg and Spink advise 23 ± 2 mm. 



MIYA; Our mice here have been acutely exposed to cold with 

 the rectal probe at 2 cm depth, and the temperature remains 

 at this level, but at 1 cm depth, it falls. This is quite similar 

 to the type of curves that you obtained. 



WALKER: I have never measured body temperature over a 

 brief period of time like that. I have always tested the amount 

 of time it takes for the probe to come to a steady state, but I 

 have not determined the temperature in the first few hours af- 

 ter exposure, 



BLAIR: One final comment, if I may, about the accuracy of 

 temperature measurement. This problem has been kicked around, 

 of course, in large animals, and it has been demonstrated that 

 the variations seem to occur during the dynamic changes in 

 temperature, but once the temperature is stabilized, it really 

 doesn't matter where you measure the so-called core tempera- 

 ture. I can't speak for the smaller animal, but certainly in the 

 large animals it does make a difference of what the point of in- 

 terest is. The changes occur physiologically and physically during 

 the actual changes of temperature, but once the temperature is 

 stabilized, it doesn't really matter where it's measured. 



WALKER: Benzinger finds considerable difference betweenrec- 

 tum and esophagus temperatures, as I recall, in the first few 

 hours, but after that, it makes no difference. 



BLAIR: So it depends upon what you are interested in studying. 



WALKER: I am not quite clear as to whether or not the effect 

 of cold on Coxsackie virus infection that you described required 

 continued exposure to cold to get this increased mortality. 



MARCUS: We didn't carry out any experiments that discon- 

 tinued; in other words, the animals were put in the cold and they 

 stayed to the continuation of the experiment, but there was no 

 discontinuous effect as you studied. 



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