SPECIFIC AND NONSPECIFIC RESISTANCE 

 DISCUSSION 



MIRAGLIA: You made a statement that the rectal tempera- 

 ture of the mouse equilibrates after 24 hours and then estab- 

 lishes a plateau that is 1 C higher than the temperature the 

 animal started out with. We found the same thing in the first 

 24 hour period, but our plateau temperature has been approxi- 

 mately the normal temperature of the mouse, rather than 1° C 

 higher. I was wondering if a possible explanation of this isn't 

 the fact that animals, in our experience, anyway, lose their 

 tails and ears after 14 to 21 days in the cold, and losing this 

 cooling surface causes them to have a slight elevation in tem- 

 perature. I noticed in Figure 9 that you kept your animals at 

 2° C for 30 days. Do you do this in all of your experiments? 



MIYA: Our acclimatization period varies. At the present time, 

 we are trying to establish some criterion for acclimatization 

 and experiments are being conducted at the present time in 

 which we are measuring the adrenal weight and animal weight. 

 We intend to do eosinophil counts and we have even thought of 

 checking for stress lymphocytes; I don't have any conclusive 

 data yet, but I feel, based on what I have read in the literature, 

 that if you used approximately thirty to forty or sixty days, 

 this is considered in the opinion of most people to be an ade- 

 quate acclimatization period. 



MARCUS: How about the loss of tails and ears? 



MIRAGLIA: Do your animals experience this? The animal 

 loses the tail completely, in our experience, and I was wondering 

 whether your animals do the same thing. 



BERRY: Yours are grouped how? 



MIYA: Five or ten together; at least five. 



BERRY: With bedding? 



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