TUNEVALL AND LINDNER 



log number of 

 pneumococci/ml blood 



^0 



Normothermic mice (7) 



16 24 32 40 48 

 5 000 pneumococci i,p. 



90 100 

 hours 



Figure 12. Results of inter vitam and post mortem blood cultures in hypothermic 

 mice and normothermic ones given 200,000 pneumococci Type II Intraperitoneally. 

 Markings as in Figure 2. 



died; one at start of revsarming, and the remaining two within 12 

 hours after this procedure. No difference as to the survival time, 

 therefore, was noted. 



DISCUSSION 



It should be pointed out that our experimental procedure for 

 attaining hypothermia was devised to decrease the body temperature 

 by elimination of the normal thermoregulation at chilling. Thus, 

 stress reactions were minimized and body temperature was rapidly 

 stabilized at 22° C to 23*^ C. 



Preliminary experiments indicated a slower increase of the blood 

 counts of pneumococci and a prolonged survival in hypothermic mice 



262 



