PREVITE AND BERRY 



agree with you, certainly, the genetic constitution of the host 

 can be just an important. 



WALKER: I think we should not expect to see an effect with 

 a very virulent strain or with a virulent virus in a very sus- 

 ceptible host. These are not the circumstances in which you 

 can see small differences. It is very important to have the strain 

 and host under the right circumstances; it seems to me we can 

 then see an effect of temperature. It's ridiculous to expect a 

 measurable effect under all circumstances. Much of the vari- 

 ation in the results reported from experimental work concerned 

 with the effect of cold on infection can be explained, I think, 

 by the variation in host and strain of infectious agent used in 

 the experimental work. 



TRAPANI: I am a little curious about something on which you 

 might like to comment. I'm thinking about the effect of ACTH 

 and corticoids, especially. We always think about their pos- 

 sible effect on the host. However, Dr. Miya's results showed 

 that bacteria can change, too, with the animal. Is it possible 

 that there is also an effect on the invading organism? Is there 

 any other work which points to this? 



MIRAGLIA: I will comment on this later on this afternoon. 



PREVITEi The data I presented would give us little direct 

 information regardii^ the role of adrenal corticoids and the in 

 vivo infectious process. My work thus far with adrenal corti- 

 coids has been centered around the effect of these hormones 

 on the response of mice to heat killed cells or commercially 

 prepared endotoxin. 



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