Role of the Lymphocyte in Antibody Formation 91 



transferred cell, somewhat more than 200 million molecules of antibody to 

 bovine serum albumin were circulating in the recipients for each cell trans- 

 ferred eight or nine days before. 



DISCUSSION 



On these observations we can base estimates concerning the minimum anti- 

 body synthesis resulting from the transfer of a known number of cells. First, 



Fig. 7-8. Recipient site 8 days after transfer of living lymph node cells. Another area. 

 Hematoxylin-eosin stain, (x 1800) 



the total antibody synthesis during the first eight clays of the response, most 

 of which occurs from the third through the sixth day after injection, is 

 probably two or more times that present in the recipient on the eighth or 

 ninth day. because considerable antibody combines with circulating antigen 

 and is rapidly catabolized. 62 Additional antibody is lost also by normal non- 



