Role of the Lymphocyte in Antibody Formation 89 



When dead cells were transferred, heterophils, host macrophages, and 

 giant cells were present in the transfer sites, but there was an insignificant 

 development of plasma cell precursors or plasma cells. 



When live cells were transferred and not stimulated by antigen, the sites 

 contained only rare plasma cells on the ninth day. 





Fig. 7-6. Recipient site 8 days after transfer of living lymph node cells. Hematow lin- 

 eosin stain. (X 140) 



The immune responses in the experiments in which live cells were trans- 

 ferred and stimulated by antigen were of the secondary or hyperimmune 

 type. On the basis of available functioning lymphoid cells, the responses 

 in these recipients were comparable in quantity and quality of antibody to 

 responses observed in intact hyperimmunized rabbits. 55 ' G0 ' 01 The elimina- 

 tion of antigen, a reflection of antibody production, was usually complete 

 by the fifth or sixth day in the recipients, whereas rabbits undergoing a 



