Role of the Lymphocyte in Inflammation 77 



as well. The nuclear membrane showed varying degrees of ridging or 

 notching. The nuclear pattern is "more open" with an apparent increase 

 of parachromatin. If observation of these cells had been started with the 

 25-hour stage, there would have been little to suggest their origin from 

 the small lymphocyte. 



Naegli Monocytic Leukemia Subject 4 



The patient suffered from chronic granulocytic leukemia (monocyte 

 leukemia of Naegli) in which he had 6,000 fully mature monocytes per 



Fk;. 6-7. Hypertrophied Km- ££ 



phocytes from a lesion similai 

 to that in Fig. 6-3, in the twenty- 

 fifth hour of inflammation in 

 man. (x 900) (Inset) Monocyte 

 from peripheral blood of volun- 

 teer at same magnification for 

 comparison, (x 900) 





\ 



cubic millimeter of blood. Their diameter was approximately 15 p, and 

 the majority (85 per cent) had prominent nuclear indentations as a tag. 

 Egg albumen was used as the inflammatory agent. 



At 7 hours the monocytes were present in moderate numbers and, 

 except for polymorphous changes of their nuclei (thin strands), had no 

 major morphologic alteration. Some of the cells showed evidence of pre- 

 cocious phagocytosis. 



At 12 hours the monocyte was the predominant mononuclear cell. 

 They were further hypertrophied (16 to 18 ^ in diameter) and had in- 

 creased evidence of phagocytosis. When a control window at 12 hours 

 and monocytic leukemia at the same interval were compared, the hyper- 

 trophied lymphocytes ranged from 8 to 12 jx while monocytes range 

 from 14 to 18 fx in diameter, and the latter are more actively phagocytic. 

 Hypertrophied monocytic series during the first 13 hours of inflammation 

 were approximately 6 fx larger than the comparable lymphocytic series. 



