Role of the Lymphocyte in Inflammation 73 



areas of inflammation. These objections have been disproved by numerous 

 investigators and are no longer tenable. The literature on these views as 

 well as the potentialities of the lymphocyte has been reviewed recently by 

 Rebuck and colleagues. '■'•■ 4 



Some of the prerequisites of readily mobilized sources of potential macro- 

 phages are: 







Fig. 6-2. Subcutaneous granuloma of sarcoidosis with numerous Lymphocytes at 

 the periphery. Hematoxylin-eosin stain, (x 560) 



1. A source of small cells readily available for transportation to the in- 

 flammatory site 



2. Access to a suitable means of transportation (blood stream) 



3. The cells must be capable of motion 



4. The cells must be capable of emigration from vessels and preferably 

 show a positive chemotaxis to the inflammatory agent 



5. The cells must be able to help destroy, contain, or "neutralize" the 

 noxious stimulus so that healing can ensue. 



The neutrophilic leukocytes, numerically the most important members 

 of the white cells in the peripheral blood, best fulfill the first four of these 



