1-f The Lymphocyte and Lymphocytic Tissue 



have been transferred from the cytoplasm of the reticular cell to the plasma 

 cells. Does this same type of transfer occnr during the production of gamma 

 globulin and antibodies? (In Figs 1-15 and 1-16 one can see a reticular cell of 

 the marrow chosen purposefully to illustrate the variety of cells which seem to 

 adhere to its peripheral cytoplasmic boundaries.) 



The transformation of reticular cells to lymphocytes seems well established. 

 Now what of the germinal center cells, the rounded forms which vary in size, 



Fig. 1-16. Same cells as in Fig. 1-15 subsequent to "coun- 

 terstaining" with Prussian blue. The gray cytoplasm ot the 

 reticular cell is actually bright blue-green (ferritin). The 

 coarse dark granules are even more strongly Prussian blue 

 positive. Note iron in neutrophils. The normoblasts contain 

 iron, but this is not apparent in the photomicrograph. 

 (X 800) 



nuclear-cytoplasmic ratio, cytoplasmic basophilia, and nuclear pattern? These 

 appear to be the most actively multiplying cells of the lymph nodes, and these 

 are the cells which cause the most confusion insofar as histopathologic or 

 hematopathologic diagnoses are concerned. 



STRUCTURE 



The various forms of germinal center cells can be seen in Figures 1-1 and 

 1-2. Germinal center cells are also illustrated by Bessis whose colored plate 

 (Plate XXI, Part I, of Reference 40) shows the varying colors of the inclu- 



