Lymphocytokaryorrhectic Effects of Adrenocortical Steroids 113 



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Fig. 9-1. Inguinal lymph node of untreated control CBA mouse. Note variation in size 

 of lymphocytes in addition to cytoplasmic variations. Hematoxylin-eosin stain (X 425) 



Fig. 9-2. Lymph node of adrenalectomized CBA mouse. Note increase in lymphocyte 

 mean cell diameter and mitotic figures. Hematoxylin-eosin stain. (X 425) 



Fig. 9-3. Treatment of intact CBA mouse with ACTH (5 days). Inguinal node showing 

 pyknosis of lymphocytes. Hematoxylin-eosin stain. (X 425) 



Fig. 9-4. Treatment of mouse with single large dose of adrenal cortical extract (i. p.). 

 Note phagocytosis of broken small lymphocytes by macrophages. Hematoxylin-eosin 

 stain. (X 425) 



to be due to increased adrenocortical discharge due to the stress of the 

 operation itself. 5 Cytorrhexis does not last more than an hour or two, and 

 then the lymphatic tissue undergoes a change toward that characteristically 

 found in adrenalectomized animals."' 



The cytologic characteristics of lymph nodes of adrenalectomized animals 

 are several. There is less discrepancy in size between large lymphocytes and 



