Lymphocytokaryorrhectic Effects oj Adrenocortical Steroids 115 



water. 8 However, the nitrogen content of the whole lymphatic node in- 

 creased as a reflection of the increased cellularity. 7 



The thymus also undergoes an increase in cellularity, and as a conse- 

 quence the demarcation between cortex and medulla grows less distinct. 





Figs. 9-6 and 9-7. Thymus ol rabbit showing pitting effect ol 

 thymus Eollowing 10 mg. ACTH (i. p.). Pitted areas are oc- 

 cupied by macrophages ingesting broken lymphocytes. Hema- 

 toxylin-eosin stain. (Fig. 9-6, X 110; Fig. 9-7, X 475) 



The increase is in the thymic cortex, which is accompanied by a big increase 

 in the number of lymphocytic mitoses. The nitrogen content per milligram 

 of thymus is not increased. 7 The mean mass of the thymus increases as com- 

 pared to nonadrenalectomized controls, and the nitrogen content reflects 



