184 The Lymphocyte and Lymphocytic Tissue 



Follicular to Lymphocytic to Reticulum Cell Lymphoma 



Case 2. This 62-year-old man gave the history of a mass developing rather 

 rapidly in his right axilla fifteen years earlier. It reached the size of a golf 

 ball and remained static until five weeks prior to admission. At that time he 

 noted enlargement of all superficial nodes, associated with progressive 



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Fig. 15-4. Case 1. Axillary lymph node biopsy diag- 

 nosed as follicular lymphoma (A) was followed a year 

 later by the development of chronic lymphocytic 

 leukemia (Ii), the peripheral leukocyte count reach- 

 ing 250.000 per cubic millimeter (all mature lympho- 

 c ytes). 



abdominal swelling. The latter was identified as massive tumor growth. 

 apparently a composite of nodal, splenic, and hepatic enlargement. Removal 

 of the original axillary mass, now the size of a tennis ball, disclosed a malig- 

 nant lymphoma of follicular type (Fig. 15-5.4). He responded well to chemo- 

 therapy, and subsequent local recurrences were treated by radiotherapy. 

 A biopsy about a year later showed complete loss of nodular pattern (Fig. 



