The Changing Pattern of Lymphocytic Malignancies I s c ) 



Mycosis Fungoides to Lymphocytic Lymphoma 



Case 6. This patient was referred from the Dermatology Service in 1953. 

 Biopsy of red. nodular skin lesions led to the diagnosis of mycosis fungoides 

 (Fig. 15-&4), regression following treatment with triethylene melamine. 





m 



Mi 





*% »/A 



Fig. 15-8. CV/.sr 5. Follicular lymphoma in mesocolic 

 lymph nodes (.-]) with coexistent mixed lymphocytic 

 and reticulum cell lymphoma in the wall <>l the 



adjacent colon (B). 



Within a month the enlargement of axillary lymph nodes indicated systemic 

 spread, and aspiration of iliac bone marrow confirmed this. However, both 

 bone marrow and lymph node biopsies were different from that of the skin, 

 the malignant process in each being purely a well-differentiated lymphocytic 

 growth (Fig. 15-95). Since then splenomegaly has been the notable manifesta- 

 tion of the lymphomatous process, occasionally coupled with nodal enlarge- 

 ment and both controlled by a minimum of radiotherapy or chemotherap) 

 as indicated. The patient remains clinically well and works steadily as a 

 commercial photographer. 



