Histopathology in Prognosis & Therapy of Lymphocytic Lymphomas 221 



occasional small islands of lymphatic tissue composed of dense sheets of 

 small lymphocytes without any follicular pattern. Mitoses were usually not 

 demonstrable. The lymphatic tissue infiltrated only between the neighbor- 

 ing row or two of fat cells and not into the myeloid tissue. Over the course 

 of years, these islands of lymphatic tissue have slowly increased in number. 

 There was adequate space for expansion of the lymphatic tissue into fat 



Fig. 17-8 (Contd.). (D) Spleen, normal architecture with clearly demon- 

 strable white pulp (WP) and cords and sinuses in the red pulp (RP). (X 80) 



without infringing on normal myeloid tissue which usually occupies only 

 20 to 30 per cent of the sternal marrow volume in the age group in which 

 chronic lymphatic leukemia occurs. 



There were patients with disease of intermediate severity between the 

 mildest form (Case 5) and the most advanced and progressive type (Case 7). 

 The transition from a less to a more severe form was marked by a gradual 

 increase in lymphatic tissue which eventually, after replacing most of the 

 fat, replaced the myeloid tissue. 



Although every patient whose marrow had had a histopathology similar to 



