The Changing Pattern of Lymphocytic Malignancies 191 



Follicular Lymphoma to Hoik. kin's Granuloma, Terminating as Acute 

 Granulocytic I <i i ki m i a 



Case 8. This is one of our rare links between lymphomatous and myelo- 

 proliferative disorders. The patient, a 76-year-old woman, noted a lump in 



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Fig. 15-10. Case 7. A rapidl) growing retroperitoneal 

 Lymphangiosarcoma (A) regressed following radio- 

 therapy, but was followed by follicular lymphoma 

 18 months later (B). At the time of the latter biopsy 

 the nodular pattern was fading and the growth was 

 assuming a reticulum cell form. 



her neck in June. 1951; it regressed spontaneously and recurred three 

 months later, the regrowth being rapid and multinodular. The biopsy 

 viewed at low magnification was folliculoid (Fig. 15-1 1.4), but the cellular 

 components were typical of Hodgkin's granuloma, complete with Reed- 

 Sternberg forms and eosinophils as part of the multiplicity of cell types 

 (Fig. 15-115). The initial growth was checked by radiotherapy, but within 

 the year generali/ed dissemination required the use of alkylating agents. 



