Histopathology in Prognosis it Therapy of Lymphocytic Lymphomas 253 

 The most important morphologic factors in evaluating prognosis and 

 response to therapy were: 



1. The dominant cell type 



2. Functional capacity of the marrow 



3. Changing histopathology 



4. Preservation of architectural pattern 



5. Development of fibrosis. 



Ancillary data modifying conclusion based upon histopathology were: 



1. Sites of involvement by malignant tissue 



2. Presence of coincidental disease 



3. Lowering of resistance to infection 



1. Presence of hypersplenic syndromes or abnormal proteins 

 5. Overtreatment. 



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