264 The Lymphocyte and Lymphocytic Tissue 



excellent colored illustrations of macrophages with phagocytized Histo- 

 plasma capsulatum and Leish mania donovani. Figure 19-2 depicts a large 

 epithelioid reticulum cell in a lymph node imprint obtained from a patient 

 with cat-scratch disease. In forming the epithelioid cell of this disease, 11 

 the nucleus has become larger and the nucleolar apparatus hypertrophied, 

 although the reticular chromatin pattern remains. The cytoplasm has in- 

 creased in bulk and presents large pseudopodial processes suggestive of 

 secretory activity. 





Fig. 19-2. Large epithelioid reticulum cell (center) surrounded by 

 small and medium-sized normal lymphocytes. Lymph node imprint 

 in cat-scratch disease. Leishman stain. (X 1100) 



STORAGE RETICULUM CELLS 



The reticulum cells may be the site of undue accumulations of lipids 

 and other substances resulting in multifocal proliferative diseases of the 

 lymphocytic and connective tissues. Characteristic of this group is the lipid 

 histiocyte depicted in Figure 19-3. The nucleus, which has remained small, 

 as in the inactive form, is largely obscured by the lipid inclusions of Hand- 

 Schuller-Christian disease which frequently consist of large quantities of 

 cholesterol lipids. The affected reticulum cells of Gaucher's disease contain- 

 ing excess cerebrosides and of Niemann-Pick's disease with excess sphingo- 

 myelin have been earlier described and depicted. 40 Plate XXX of Diggs's 

 work 1 - has colored illustrations of typical lipid histiocytes in these latter 



