266 The Lymphocyte and lymphocytic Tissue 



multifocal proliferative condition, is Whipple's disease, excellent illustra- 

 tions of which, as well as the original description, are afforded by Sieracki. 54 

 Section studies of perpiheral lymph nodes supplemented by the imprint 

 method may now yield information of specific diagnostic importance in 

 this condition and in Hurler's disease in which similar cells containing 

 spindle particles have been recently described. 32 



SARCOMATOUS RETICULUM CELLS 



Beyond reaction, however, is reticulum cell sarcoma. As large as the 

 various malignant reticulum cells of this condition appear in sections, their 



Fig. 19-4. A group of malignant reticulum cells in a lymph node 

 imprint of reticulum cell sarcoma. Leishman stain, (x 1100) 



bizarre, blastlike chromatin patterns, unusual nuclear configurations, and 

 their nucleolar multiplications can only be truly appreciated with the more 

 refined cytologic method seen in the lymph node imprints of reticulum 

 cell sarcoma (Fig. 19-4). In contrast to the reaction forms of the reticulum 

 cell (Figs. 19-1, 19-2. 19-3), the cytoplasmic nuclear ratio now favors the 

 hypertrophic malignant reticular nucleus. The cytoplasm is scant, varyingly 

 basophilic, and prone to vacuolar degeneration. The leukemic manifestation 

 of reticular malignancy of this type is usually classified in the literature 

 as monocytic leukemia, and indeed differentiation to the monocytic line 

 from the malignant reticulum cell does occasionally occur (Fig. 19-10 and 

 Fable 19-2) and receives the eponymic designation of Schilling's type of 



