SCHMIDT 



20 



^ Hibernating 



■♦- Specimen - Positive 

 for VIRUS 



- Specimen - Negotive 

 for VIRUS 



I 10 22 5! 13 17 23 24 45 



ARCTIC GROUND SQUIRRELS GIVEN ECHO-6 VIRUS 



Figure 3. Arctic ground squirrels given Echo-6 virus. 



The results of the ECHO-6 studies are shown in Figure 3. 

 As in the case of the bacteriophage, it can be seen that the virus 

 soon disappeared from the intestinal tract of the active animals 

 but could be recovered from the hibernators up to 18 days after 

 administration. Two of the squirrels were still excreting virus 

 when the last sample was collected. 



Essentially the same effect was observed in the case of the 

 Coxsackie B-3 virus, as shown in Figure 4. The period of re- 

 tention in the active animals was somewhat longer than that ob- 

 served for the bacteriophage and ECHO-6 virus, but these dif- 

 ferences may be more apparent than real. 



As to the fate of the virus introduced, none of our data gave 

 any evidence that viral replication had occurred. Indeed, we re- 

 covered considerably less virus than we administered. 



Dempster et al. (1961) report that Coxsackie B-3 virus is in- 



408 



