TEMPERATURE AND VIRAL INFECTION 



Figure 6. Effect of environmental temperature on the body temperature of mice. 

 Eich. point represents the mean of the rectal temperatures of 10 mice. (Walker, D. L., 

 and Boring, W. U. 1958. J. Immunol. 80: 39-44.) 



demonstrated that at 4° C the mouse's internal temperature is 

 lowered about 1° C to 2° C and exposure to 36° C raises the rectal 

 temperature about 2° C to 3° C (Fig. 6). 



These phenomena suggest that in the host cell there are tempera- 

 ture-sensitive reactions that can control Coxsackie virus multi- 

 plication. Additional support for this has been provided by Boring 

 and Levy (1962) who demonstrated that in HeLa cells in vitro the 

 optimum temperature for multiplication of the Conn.- 5 strain of 

 Coxsackie virus is 36° C and that multiplication is markedly in- 

 hibited at 38° C to 39° C, and is also reduced at temperatures below 



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