TEMPERATURE AND VIRAL INFECTION 



Inoculum 

 (i. p. ) 



Environmental 

 temperature 



Deaths**/no, inoc. 



Virus 

 Suspension* 



25° C 

 »+o C 



0/20 

 19/20 



Normal mouse 

 tissue suspension 



25° C 



4° C 



0/20 

 0/20 



Figure 1. Lethal effect of Coxs^ckie virus infection in adult mice at 4° C. *4000 

 LD-^ for infant mice. ••No. of mice dying during 10 days of observation. 



Ambient temperature 

 C 

 Before After 



inoculation* inoculation 



Deaths /no. 

 inoculated 



Figure 2. Relationship of time of exposure to coUl ami lethal effect of Coxs;ickie 

 virus in adult mice. 'ISOO infant LIJ50 given 1. p. ••Deaths in 10 uay observation period 

 after mice placed at 4'^ C. 



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