COLD AND COLDS 



sponsible, there has not been one single instance of a cold, and 

 furthermore, no pneumonia, so I think that this would support 

 your idea that chilling is probably not of any importance in the 

 development of a cold. 



CAMPBELL: Of course, it's been a long time since I have had 

 bacteriology; we used to think that bacteria may be involved 

 here. You didn't mention bacteria at all. I just wondered whether 

 in your studies you had found any correlation between bacterial 

 flora and virus infection? 



ANDREWES: Well, 1 think everybody agrees that in the late 

 stages of the cold, secondary infection with bacteria comes and 

 causes the sinusitis and the yellow , muco-purelent stuff. This 

 is generally about in the early stages of the cold; it is very 

 difficult to find anything abnormal about the bacterial flora then, 

 but there is no doubt that in the later stages they do come in 

 and confuse the picture. 



CAMPBELL: But no particular type, I mean. 



ANDREWES: No, it varies, I think. 



WALKER: Have you done any studies on immunity to the com- 

 mon cold? Jackson and Dowling, 1 believe, report a surprisingly 

 slow development of the immunity. 



ANDREWES: Well, yes, we are studying that, and we agree 

 with them that the immunity seems to be specific. We have one 

 of the people working at Salisbury, Dr. Periera, who is the origin 

 of the HGP strain of virus, and he has been bled at intervals. 

 His serum, before he had a certain cold in 1957, had no anti- 

 bodies to his strain. Then he had this attack of cold and his 

 antibodies came up pretty quickly. Since then, he has been fol- 

 lowed along and he has had several colds and we have gotten 

 different viruses from him. The original HGP virus is one of 

 the ones that grew in monkey tissue. One of the other strains 

 was one that didn't grow in monkey, but would grow in human 

 tissues and another was a strain which would transmit colds to 

 volunteers, but we couldn't grow it at all. All this time he has 



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