BLAIR 



ss 



SS*H 



ss 



SS*H 



Figure 10. Ventilation in septic shock (closed circles) and septic shock with hypo- 

 thermia (open circles), Vg, "oxygen consumption; V-p ■= minute ventilation. During septic 

 shock, an increased degree of breathing was required to yield a given amount of oxygen. 

 Hypothermia significantly allayed this undue ventilatory work by reducing oxygen re- 

 quirement (MROg). 



computed. Cultures of the blood stream were done 0, 15, 30, and 

 60 minutes after instillation of feces. White counts and differ- 

 entials were done also prior to and after septic shock in both 

 groups. It is emphasized the animals received no fluids or treat- 

 ment other than hypothermia in the S.S. + H. group, except for 

 replacement of blood removed for analysis. 



Results of Experimental Study 



Mortality. Figure 8 shows the mortality rate in both groups. 

 Eighty- six per cent of the animals died in septic shock in four 

 hours, and all died within six hours after fecal instillation. In 

 the hypothermic group 13 per cent died by the four-hour period, 

 88 per cent by 10 hours, and all by around fourteen hours. Hypo- 

 thermia did not save any of the animals, but it did prolong survival 



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