COLD AND VIRUS INFECTIVITY 



that you used ACTH, and this apparently didn't enhance viral 

 multiplication. What was the regimen that you used and how many 

 injections did you give? 



WALKER: Four mg in gel, as I recall, given every twelve 

 hours for a period of six days. ACTH has been shown very rarely 

 to have an effect upon viral infections in the mouse. I don't 

 understand why it should not. You showed the effect of ACTH 

 upon toxin, but this may be quite a different thing. ACTH does 

 produce physiological changes in the mouse that indicate that 

 the ACTH is active, but the failure of ACTH to aggravate viral 

 infections seems to be a peculiarity of the mouse. Cortisone 

 has quite an effect upon viral infection in the mouse, but ACTH 

 has very little. 



McCLAUGHRY: Certainly the thesis that Dr. Watson has pre- 

 sented appeals to me very much as a person interested in human 

 physiology because of the fact that the general pattern of inter- 

 actions of related functions of cells and tissues fits the category. 

 The modifications of a particular kind of cell reaction or tis- 

 sue reaction modifies the balance among all functions, and there- 

 fore, the modification of temperature at which cells are held 

 might very well favor certain enzymic processes which would 

 be involved, perhaps, in replication of viral protein as compared 

 with certain other cellular processes. 



MARROW: Does the level of interferon which responds to 

 the increase in temperature account for part of this decrease 

 in virulence with increased temperatures? 



ANDREWES: I think it may work another way. Is sacs gave 

 a review on interferon at the Montreal meeting; one of the things 

 that he mentioned was that he has been in touch with Lwoff about 

 this, and he feels, concerning the virulence of the strains of 

 virus which do better at high temperatures, that perhaps they 

 are able to do so because they become less sensitive to the 

 action of interferon. 



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