COLD THERAPY IN BACTEREMIC SHOCK 



220 

 200' 



leo 



140 

 120 



too 



80 

 60 

 40^ 

 20' 

 



,». •■ • hCART RATE 



.A, 



X' \ ^ MEAN ARTERIAL 



>'■ \ BLOOD PRESSURE 



» VENTILATORY RATE 



2 3 35 4 



HOURS 



Figure 11. Example of a septic shock study. Concomittant with massive bacterial in- 

 vasion of the blood stream, the temperature rose, arterial blood pressure dropped, 

 ventilation and heart rates accelerated. 



significantly. 



Physiologic changes. Figure 9 demonstrates alterations in 

 ABPm, HR, and Vj^. Septic shock was characterized by significant 

 fall in ABPm, by tachycardia, and by hyperpnea. Hypothermia 

 resulted in a further fall in ABPm, and a slowing of HR and Vj^ to 

 or below pre-septic shock values. Non- cooled dogs prior to death 

 underwent serious reduction in the compensating hj^ierventilation. 

 Vq and "C^-p (minute ventilation) values are shown in Figure 10. 

 V02 in septic shock remained essentially similar to pre- infection, 

 with an increased V-p.Upon cooling, Voo ^^'^ Vrj. declined appreciably. 



431 



