BLAIR 



J2 



50- 



220 

 200 



MEAN ARTERtAL 

 BLOOD PRESSURE 



4 45 6 



HOURS 



K) 12 



Figure 12. Example of a septic shock and hypothermia study. Note again onset of shock 

 shortly after flooding of blood stream. This likely represents period of failure of clear- 

 ance mechanisms of the blood stream. Under hypothermia the arterial blood pressure 

 changed little, but ventilation and heart rates slowed considerably. Upon rewarming, 

 heart rate re- accelerated and ventilation decreased, but not to previous high pre- 

 hypothermic level. 



Examples of the course of events in an animal from each group are 

 illustrated in Figures 11 and 12. Hypotension, tachycardia, and hyper- 

 pnea developed at about the same time the blood stream was over- 

 whelmed with bacteria. The hypothermic dog lived for 14 hours, and 

 then succumbed after it had beenrewarmed. Positive blood cultures 

 persisted during the hypothermic period. Effects on A-Vqo appear 

 in Figure 13. There was a marked widening (three times normal) 

 which indicated increased extraction of oxygen. At the time of death 

 the A-Vq2 widened further, while in the cooled septic dogs there 



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