BLAIR 



Time Minutes 



15 30 



Hours 

 2 3 



Per cent 

 initial 



Per cent 



TNTC 



30 45 



25 



50 37 13 



Figure 15. Percentage rate of appearance time of micro-organisms in blood stream. 



WBC IN 

 THOOSANDS 



• SEPTIC SHOCK CONTROLS 



SEPTIC SHOCKS HYPOTHERMIA 



Figure 16. White blood count in septic shock. A marked leucopenia developed with 

 stabilization and some improvement under hypothermia (32° C). Just before death in 

 the hypothermic group, there was a further fall in white blood cells. 



was a reduction toward, but not to, normal. 



Bacteriology . The most common organism cultured from the blood 

 stream was Escherichia coli (Fig. 14). Cultures included also Strep- 

 tococcus , Pseudomonas , and Aerobacter. Combinations of E. coli 

 with these were frequent. Bacteria were detected in the blood stream 

 as early as 15 minutes after inoculation (Fig. 15). The blood stream 

 was overwhelmed within two hours, which was about the same time 

 severe shock developed. Cultures remained positive during the 

 h3T)othermic period. 



Leucoc3^ic response. A severe leucopenia developed in both 

 groups, reaching its most advanced state at the time of death 

 (Fig. 16). Induction of hypothermia stabilized the level of white blood 

 cells. There was also a tendency for some increase in count, but 



434 



