COLD THERAPY IN BACTEREMIC SHOCK 



HYPOTHERMIA 



SM-2 SH-3 SH-4 



Figure 17. Differential counts demonstrate the leucopenia was due primarily to re- 

 duced granulocytes. 



the series is too small to attach significance to this. There was 

 a further drop just before death, as occurred in the non- cooled 

 group. The leucopenia was due primarily to disappearance of 

 granulocytes (Fig. 17). Lymphocytes show a relative rise in 

 count with no apparent alteration in monocjdes. Cooling resulted 

 in no further change in the differential; only a temporal extention 

 of the pattern was noted. 



Discussion of Experimental Study 



Criticism of experimental preparation. Septic shock in the dog is 

 not the same as in the human. Avulsion of the cecum may produce a 

 preparation more similar (Pulaski et al. , 1954). In the study per- 

 formed here the inoculum was homologous. The temporal relation- 

 ship also was considerably shorter. Better control of bacteriologic 



435 



