BLAIR 



%>N 



Figure 18. Relation of minute ventilution (V^) to oxygen consumption. For details 

 see text. 



effects per se may be obtained if a pure strain of E. coli had been 

 used instead of coliform mixtures, which varied with each inoculum. 



In this study, interest was centered primarily on the general 

 physiologic and metabolic effects of septic shock alone and as modi- 

 fied by the augmented level of hypothermia.There is less operative 

 trauma with fecal instillation, and the entire study can be completed 

 within 6 to 12 hours. Particularly interesting is the fact that the he- 

 modynamic and hematologic pictures are similar to those caused by 

 endotoxin (Spink,1960;Gilbert,1960). The mixed flora is more akin to 

 the clinical insult thanpureendotoxinor E, coli. One significant dif- 

 ference between endotoxin and coliform induced changes is that Vq^ 

 is not decreased as much, whereas Vrp is greater with coliform sep- 

 sis (Maxwell etal.,1960).Increase or no change in Vq^ and at least an 

 initial increase in Vrp are characteristic of the clinical syndrome. 



Hypothermic effects . Septic shock in these preparations resulted 

 in an increased work load on the cardiopulmonary systems. Response 

 was adequate to a point, but with progressive crippling from the tox- 

 emia, compensatory mechanisms broke down. The animal descended 



436 



