BLAIR 



antibiosis and supportive therapy. The underlying physiologic dys- 

 function appears to be hypoxia secondary to a tissue perfusion 

 deficit. The rationale of hypothermia lies in the reduction of MRO^ 

 in order to place tissue needs at a level more commensurate with 

 the reduced blood flow. The action of hypothermia is non-specific. 

 Its effect lies in the modification of the host metabolic environment. 

 The augmented level of 32° C has proved effective and safe and 

 likely does not alter bacterial growth. 



ACKNOWLEDGEMENTS 



The able assistance of George Henning, Allan Land, Luther 

 Leibensperger, Dorothy Suter, McRae Williams, and Joseph Wilson 

 was most valuable. This study was supported by U. S, Public Health 

 Service Grant No, HE-06154-02 and Research Career Award No. 

 HE-K3-4232(C1) and by a grant from OTSG, U, S. Army Research 

 and Development Command, 



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logic action of Clostridium oedematieus (Novyi) toxin in dogs. 

 J. Clin, Invest. 26: 404-411. 



3. Balch, H. H., H. E, Noyes, and C, W, Hughes, 1955, The influence 



of hypothermia on experimental peritonitis. Surgery 38:1036- 

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