GENETIC STRAINS AND STOCKS 



705 



inbred strains and strains in development is not yet too great, standardization of nomen- 

 clature and symbols at the present time should avoid the confusion that once existed 

 for mice. Consequently, ( 1 ) the rules recommended by the Committee on Standardized 

 Genetic Nomenclature for Inbred Strains of Mice should be adopted for inbred rat 

 strains, and (2) the symbols used in the following table should be immediately adopted. 

 The international rules of gene and strain nomenclature are discussed in the chapter 

 by Miss Staats. Perhaps the Committee will be asked to extend its jurisdiction to 

 rats. 



The symbols for strains used in the following listing are based on the rules for mice. 

 Concurrence for the use of these symbols was obtained from most of the contributors 

 maintaining the strains. The descriptions of the strains are similar to those previously 

 used for mice with the exception of identified genetic characteristics which have been 

 included as part of the characteristics, since the genes are unknown except in the 

 genetic stocks maintained by Dr. E. Dempster. This list of contributors at the end of 

 this section is in the same format as the list for mice. The abbrevatiations were checked 

 in order to avoid duplication, and, if a contributor appears on both lists (or all lists), 

 the same abbreviation of the name is used. 



Table 28 

 Established strains of rats 



Name or 

 Symbol 



Synonym(s) 



Remarks 



ACI 



ACH 



ALB 



A990 



AXC9935, 

 AXC9935 

 Irish, 

 Irish 



AXC9935 

 Piebald 



Albany 



August 990 

 I, D (brown 

 hooded). 



inbr: F 65 . origin: Curtis and Dunning at the Columbia University 

 Institute for Cancer Research, 1926, to Heston, 1945, at F 30 , to 

 N 1950 at F 41 ; subsequent sublines from either Du or N colonies. 

 charac: life span 21.7 + 0.17 mo., susceptible to estrogen-induced 

 tumors, the N subline exhibits a high incidence of kidney abnormalities 

 (from cystic kidney to kidneys absent, unilaterally or bilaterally), 

 spontaneous Leydig cell tumors (25%) and anterior pituitary tumors 

 (15%) in old animals, a high incidence of uterine abnormalities 

 (horns absent, etc.), some resistance to Bartonella irffection, susceptible 

 to bronchiectasis (40%) and otitis media (60%), will grow trans- 

 plantable tumors M-C961, 969, 970, 972, positive for R-l factor 

 hemagglutinogen B, the Br subline shows low defecation response and 

 high activity response in open-field test of emotional behavior, black 

 agouti, irish. maintained by: Brh, Du, Ko, N, Seg. 



inbr: F 51 + . origin: Curtis and Dunning, 1926, at the Columbia 

 University Institute for Cancer Research, charac: high incidence of 

 spontaneous lymphosarcoma of illeocecal mesentery, will grow 

 transplantable tumors R2788, R2572, IRS6820, B-P839, black agouti, 

 hooded, maintained by: Du. 



inbr: F 2 i +. origin: Wolfe and Wright, Albany Medical College, 

 to N 1950; no inbreeding records available prior to the transfer to N; 

 b x s matings since, charac: exhibits some mammary fibro- 

 adenomata, negative hemagglutinogen B, large body size, docile, good 

 reproduction, nonagouti, brown, maintained by: N. 



inbr: F 61 . origin: Inbreeding started at Columbia University 

 Institute for Cancer Research by Curtis in 1921. charac: life span 

 14.03 ± 0.03 mo., resistant to Cysticercus, susceptible to estrogen- 



