GENETIC STRAINS AND STOCKS 

 Table 28 — Continued 



107 



Name or 

 Symbol 



Synonym(s) 



Remarks 



CAS 



C2331 



F344 



Hunt's Caries 



Susceptible, 



CA/S 



Copenhagen 



2331 



Fischer 344, 

 Fischer 



LEW 



M520. 



Lewis 



Marshall 520, 

 M-520 



M14 



M17 



MR 



Mi4, L4 



Mi7, H7 



Maudsley 

 Reactive 



inbr: F 38 . origin: Hunt, 1937. charac: high incidence of dental 

 caries, negative R-l factor hemagglutinogen B, poor reproduction, 

 susceptible to respiratory infections, albino, maintained by: Hun, N. 

 inbr: F 53 . origin: Curtis, at the Columbia University Institute for 

 Cancer Research, 1921. charac: life span 19.08 ±0.18 mo., 

 spontaneous tumors of thymus, resistant to estrogen-induced mammary 

 tumors, susceptible to estrogen-induced bladder tumors, resistant to 

 Cysticercus, will grow (100%) transplantable tumor IRS4337, 

 positive R-l factor hemagglutinogen B, coat color black, agouti, 

 hooded, maintained by: Du. 



inbr: F 75 . origin: Curtis at the Columbia University for Cancer 

 Research 1920, to Heston 1949, to N 1950 at F 51 , subsequent sublines 

 from either the Du or N colonies, charac: life span 12.3 + 0.10 mo., 

 susceptible to Cysticercus, uniform body size (small), susceptible to 2- 

 acetylaminofluorine-induced mammary tumors, will grow transplant- 

 able tumors IRC741, IRS1548, L-C18, IRS9802, R3211, R3230, 

 R3251, R3259, N subline exhibits 15% spontaneous tumor incidence 

 of the anterior pituitary gland, uterus and mammary gland, 30-50% 

 incidence of Leydig cell tumors, granulomatosis lesions of the lymph 

 nodes and spleen, old animals manifest otitis media (40-60%), 

 bronchiectasis (61-70%), nephritis (21-30%), myocarditis (21-30%); 

 negative R-l factor hemagglutinogen B, albino (carries nonagouti, 

 black, hooded), maintained by: Dem, Du, Fu, Gm, Hi, Ko, N, Nl, 

 Rot, Seg, Sy, Ta. 



inbr: F 36 . origin: Lewis from Wistar stock, to Aptekman and 

 Bogden, 1954, at F 20 , to Silvers, 1958, at F 31 . charac: negative R-l 

 factor hemagglutinogen B; homozygous for red cell antigen C, iso- 

 histogenic, docile, high fertility, will grow transplantable carcinoma 

 # 10, lymphoma # 8; albino, maintained by: Ss, Mai. 

 inbr: F 76 . origin: Curtis, 1920, at the Columbia University In- 

 stitute for Cancer Research, to Heston, 1949, at F 49 , to N, 1950 at F 51 . 

 charac: life span 13.5 + 0.09 mo.; susceptible to Cysticercus; spon- 

 taneous tumors rare in Du subline; N subline exhibits 21-25% 

 incidence of adrenal medulla tumors; susceptible to 2-acetylamino- 

 fluorine induced tumors; medium susceptible to Bartonella; manifests 

 high incidence of otitis media (71-80%), bronchiectasis (60%), 

 nephritis (60%), periarteritis (20%), cecitis (20%), infections of the 

 Harderian gland (100%); will grow Jensen sarcoma, Yoshida ascites 

 sarcoma (80%), hepatoma 7974 (75%), hepatoma 130 (70%); 

 negative R-l factor hemagglutinogen B; albino (carries black, non- 

 agouti, hooded), maintained by: Du, N. 



inbr: F 40 +. origin: A. B. Chapman, 1940, from Sprague-Dawley 

 stock, selection for low ovarian response to pregnant mare serum. 

 charac: low ovarian response to pregnant mare serum; albino. 

 maintained by: Cp. 



inbr: F 40 +. origin: A. B. Chapman, 1940, from Sprague-Dawley 

 stock, selection for high ovarian response to pregnant mare serum. 

 charac: high ovarian response to pregnant mare serum; albino. 



MAINTAINED BY: Cp. 



inbr: F 18 +. origin: P. L. Broadhurst, 1954, from a commercial 

 Wistar stock; selection for high defecation response, charac: high 

 defecation response in the open-field test of emotional behavior as 

 well as a heightened susceptibility to certain motivating stimuli; 

 albino, maintained by: Brh. 



