DO GENETIC STOCKS AND BREEDING METHODS 



Table 21 —Continued 



Name or 

 Symbol 



Synonym (s) 



Remarks 



The one living BALB/c $ was mated to a C57BL d*; selection and in- 

 breeding led to development of the CC57BR and CC57W mice. 

 charac: do not develop spontaneous mammary tumors; 55% tumors 

 after administration of milk factor to newborn, 15% pulmonary 

 adenomas in old mice, some leukemia and skin cancer appear; 100% 

 pulmonary tumors after urethan treatment. Viability and fertility 



good. MAINTAINED BY: Mv. 



CE Cd, c e , ce inbr (Jax): ? + 25. genet: A w A w c e c e . origin: wild mutant trapped 



in 1920 in Illinois by J. E. Knight. Detlefsen studied genetics of the 

 color type. Inbred by Eaton at least 15 generations, some sent to 

 Woolley prior to 1940. Woolley to Speirs, back to Woolley and Jax 

 in 1948. charac: low incidence of mammary tumors, 33% ovarian 

 tumors in old age, some sarcomas, wide range of tumor types, high 

 adrenal cortical carcinoma incidence after neonatal gonadectomy, 

 poor breeders, have relatively few litters but eight to ten per litter. 

 maintained by: Di, Hu, Jax, Lab, Pi. 



CFCW inbr (Rl): 29. genet: ccCaCa. origin: from Carworth Farms in 



1948. MAINTAINED BY : R 1 . 



CFVV inbr (Rl): 25. genet: cc. origin: Webster to Carworth Farms; 



distributed by them, charac: 20% mammary tumors in breeders 

 9-10 mo.; susceptible to many viruses, maintained by: Hd, Ms, Rl. 



CHI inbr (St): 93. genet: +. H-2". origin: Strong (see C3H/St). 



charac: similar to C3H/St. maintained by: St. 



CT inbr (Ch): 24. genet: aabbddpp. origin: Chase, developed for color 



testing, maintained by: Ch. 



C3H/An inbr (Wi): 82. genet: +. origin: see C3H/St. A litter of 4 ? and 



2 o* sent to Andervont in Oct., 1930. Selected in early generations 

 for high and early mammary tumor incidence, charac: over 90% 

 incidence of mammary tumors in breeders and virgins. Higher mam- 

 mary tumor and hepatoma incidence and lower pulmonary tumor 

 incidence than St subline. Mammary tumors 94% at 8-10 months, 

 almost 100% at 14 months. Hepatomas: $$ over 1 year 10%, <S<$ 

 over 1 year 27%. Pulmonary tumors in ?? 4%, o*<j 8%. main- 

 tained by: Gl, Pa, Sp, Wi. 



C3H/Bi Z inbr (Cr): 56, (Dec. 1957). genet: +. origin: see C3H/St. Strong 



to Bittner, 1931. charac: mammary tumors 90% in breeders. 

 18.4% develop leukemia when given Gross leukemia virus, main- 

 tained by: Cbi, Cr, Go, Lhm. 



C3H/Crgl/2 C3HNT/Crgl inbr (Crgl): 9, prev. 20 + . genet: +. origin: from one female of 

 C3H/Crgl which died at 29 mo. without mammary tumor, charac: 

 about 5% mammary tumors at 20 mo. in breeders, maintained by: 

 Crgl. 



C3H/He 



inbr (He): ? + 84. genet: +. H-2 k . origin: see C3H/An. 

 Andervont to Heston in 1941 after 35 b x s generations by An. 

 charac: 97% mammary tumors in breeders 7-8 mo., 100% in virgins 

 10-11 mo., 85% hepatomas in gg at 14 mo. Low red blood count. 

 1 .2 % develop leukemia when given Gross leukemia virus. An and He 

 sublines have predominantly six lumbar vertebrae, maintained by: 

 Am, Chr, Crgl, De, Di, Gif, H, He, Icrc, Jax, Jb, Kp, Lab, Mas, Ms, 

 N, Rl, We. 



